George Albert "Sam" Shepperson was born in Peterborough, Northamptonshire in 1922. He received his early education at King's School, Peterborough, before advancing to St. John's College, Cambridge. His studies were interrupted by World War II, during which he served in the Northamptonshire Regiment and was seconded to the King's African Rifles, seeing action in East Africa, India, and Burma from 1942 to 1946. His wartime experiences, particularly with a Nyasa battalion in Burma, left an indelible mark on him, fostering a lifelong connection with Africa and its peoples. He became fluent in Chinyanja and developed a profound respect for Malawi and its history.

Upon returning to civilian life, Shepperson completed his history degree and joined the University of Edinburgh as a Lecturer in Imperial and American History in 1948. He became a Senior Lecturer in 1960, a Reader in 1961, and finally, in 1963 he was appointed to the William Robertson Chair of Commonwealth and American History. His courses became renowned, inspiring many students who would go on to become prominent authorities in their fields. He retired in 1986.

Shepperson's scholarly contributions were vast and influential. His seminal work, Independent African: John Chilembwe and the Origins, Setting, and Significance of the Nyasaland Native Rising 1915, co-authored with Tom Price and first published in 1958, remains a cornerstone in the study of African nationalism. This work was pivotal in cementing John Chilembwe's status as a key figure in African history and is still regarded as one of the most comprehensive studies on Malawian nationalism. Throughout his career, Shepperson remained a committed advocate for African independence, particularly for Malawi. He also authored David Livingstone and the Rovuma in 1964, among many other significant publications.

His expertise and passion for African history led him to numerous prestigious visiting professorships, including stints at Roosevelt and Chicago Universities in 1959, Makerere College in Uganda in 1962, Dalhousie University from 1968 to 1969, and Rhode Island College in 1984.

Shepperson was instrumental in curating two University of Edinburgh Library's exhibitions, "A Miscellany of Americana" in 1963 and "A Miscellany of Africana" in 1966, which significantly enhanced the university's status in Americanist and Africanist studies. His efforts also included generous donations of books and papers, enriching the library's resources and inspiring others to contribute. He was a founding member of the Friends of the University Library in 1962, serving multiple terms on its committee.

George Albert Shepperson passed away on 2 April 2020, at the age of 98, in Peterborough, UK. His legacy is one of profound scholarly impact and passionate advocacy for African history and culture.