"This woman is very excitable, only so-so. Nurse says this woman has a progressive deterioration of the motor nerves - will die in about 6 years. (Nurse at first called it locomotor ataxia but did not mean this). They are difficult people and give a lot of trouble. Dr - progressive muscular atrophy. None of the daughters are normal and daugher is definitely MD."

Daughter 4.66, granddaughter 4.67

Contains a copy of the application form and related correspondence, and a copy of the report of the inspection visit by the HFEA to Roslin Institute's Department of Gene Expression and Development on 2 November 2004.

Typed case summary, correspondence, notes and charts relating to female patient from Scotland (outside Edinburgh and the Lothians) aged 17 at first examination in 1941. Conditions mentioned include: headache; back pain; hysterical amnesia; lower motor neuron affection; and hysterical paresis. No treatment given. Patient discharged.

Typed case summary, notes, charts and correspondence relating to male from Edinburgh and the Lothiansaged 39 at first examination in 1943. Conditions mentioned include: spastic drop-foot; muscle weakness; cortico-striatal spinal degeneration; speech issues; and motor neurone disease. No treatment given. Patient discharged.

Typed case summary, charts and correspondence relating to female patient from Edinburgh and the Lothians aged 43 at first examination in 1943. Conditions mentioned include: spastic para-paresis; and lateral sclerosis. No treatment given. Patient discharged.

Report and correspondence relating to male from Scotland (outside Edinburgh and the Lothians) aged 44 at first examination in 1944. Conditions mentioned include: motor neuron disease. No treatment given. Patient discharged.

Chart and correspondence relating to female patient from Great Britain (excluding Scotland) aged 35 at first examination in 1944. Conditions mentioned include: motor neurone disease; amyotrophic lateral sclerosis. No treatment given. Patient discharged.

Typed case summary and correspondence relating to male from Scotland (outside Edinburgh and the Lothians) aged 59 at first examination in 1944. Conditions mentioned include: lateral sclerosis of cord; backache; arteriosclerosis; and drop foot. No treatment given. Patient discharged.

Typed case summary, charts, reports, notes, photographs and correspondence relating to male from Scotland (outside Edinburgh and the Lothians) aged 31 at first examination in 1944. Conditions mentioned include: swelling; headache; parotitis; dizziness; motor neurone disease; work accident; shoulder pain; bulbar palsy; and facial palsy. Surgical treatment given. Patient discharged.

Typed case summary, chart and correspondence relating to female patient from Edinburgh and the Lothians aged 57 at first examination in 1944. Conditions mentioned include: muscle weakness; and motor neuron disease. No treatment given. Patient discharged.